Antetokounmpo has been dominant this season, averaging 30.9 points per game (second in the league) and 13.2 rebounds (fifth).
The 25-year-old is coming off a 32-point, 15-rebound, 8-assist performance in a win over the Magic on Monday.
The defending MVP and three-time All-Star has not missed a game yet this season.
The Bucks are currently the top team in the Eastern Conference. Wednesday’s opponent, New Orleans, has lost nine straight.