The White Sox said X-rays were negative and that Anderson will be re-evaluated on Wednesday.
Anderson planted his right foot awkwardly on the wet dirt behind second base after fielding a grounder and throwing to first. He hopped a few steps on his left leg before falling to the ground in obvious pain.
Manager Rick Renteria and a trainer put Anderson on their shoulders and helped him to the dugout, keeping all weight off his right leg.
The start of the game was delayed 24 minutes because of rain, which continued to fall — heavily at times — through the first five innings.
The Associated Press contributed to this report.