Harper was hit by Dellin Betances with an 89-mph slider with nobody out in the top of the inning. After taking a few steps toward first base, Bryce trotted back to the dugout and did not return to the game. He was replaced by Brian Goodwin.
Manager Dave Martinez said Harper left the game for precautionary reasons and that Harper is expected to be back in the lineup on Wednesday.
Harper was also hit on his right elbow by a 90-mph pitch from CC Sabathia in the fifth inning and fell to the ground.
Harper walked in his first two plate appearances Tuesday night. He is hitting .215 since May 1, dropping his average to .228.
According to ESPN Stats & Information research, Tuesday marked just the second time in Harper’s career that he was hit by a pitch multiple times in a game, the other coming in 2013.
The Associated Press contributed to this report.