Paxton had allowed three runs on three hits (two home runs) in two-thirds of an inning in Anaheim, California. Chasen Bradford came into relieve Paxton.
Paxton’s start was bumped up a day, taking the place of Felix Hernandez, who was put on the 10-day disabled list for a stiff lower back.
An extended absence of Paxton would be a blow for Seattle. The left-hander has 155 strikeouts this season, the fifth-most in the American League and the most by a Mariners pitcher before the All-Star break since Randy Johnson in 1998 (170).
Paxton made 24 starts and threw 136 innings, both career highs, in the majors last season.